Enhanced Surfactant Adsorption via Polymer Depletion Forces: A Simple Model for Reversing Surfactant Inhibition in Acute Respiratory Distress Syndrome
نویسندگان
چکیده
منابع مشابه
Enhanced surfactant adsorption via polymer depletion forces: a simple model for reversing surfactant inhibition in acute respiratory distress syndrome.
Lung surfactant adsorption to an air-water interface is strongly inhibited by an energy barrier imposed by the competitive adsorption of albumin and other surface-active serum proteins that are present in the lung during acute respiratory distress syndrome. This reduction in surfactant adsorption results in an increased surface tension in the lung and an increase in the work of breathing. The r...
متن کاملPolymer Depletion Forces and Surfactant Adsorption
Introduction Lung surfactant is a mixture of lipids, primarily dipalmitoylphosphatidylcholine, and several specific proteins, that lines the interior of the lung alveoli. Lung surfactant lowers the interfacial tension in the lungs, thereby insuring a negligible work of breathing and uniform lung inflation. The absence of lung surfactant in premature infants leads to neonatal Respiratory Distres...
متن کاملSurfactant medication for acute respiratory distress syndrome.
Background. Patients with acute respiratory distress syndrome (ARDS) have a deficiency of surfactant. Surfactant replacement improves physiologic function in such patients, and preliminary data suggest that it may improve survival. Methods. We conducted a prospective, multicenter, double-blind, randomized, placebo-controlled trial involving 725 patients with sepsis-induced ARDS. Patients were s...
متن کاملSurfactant treatment for acute respiratory distress syndrome.
OBJECTIVE To determine prospectively the efficacy of surfactant in acute respiratory distress syndrome. STUDY DESIGN Twenty patients, 1 month to 16 years of age, diagnosed with an acute pulmonary disease with severe hypoxaemia (PaO2/FiO2 < 100) (13 with systemic or pulmonary disease and seven with cardiac disease) were treated with one to six doses of 50-200 mg/kg of porcine surfactant admini...
متن کاملExogenous surfactant in acute respiratory distress syndrome: more is better.
Pulmonary surfactant is a complex of highly active phospholipids and proteins that cover the alveolar epithelial surface of the lungs [1]. Surfactant is synthesized in the alveolar type-II cells, stored in the lamellar bodies, and secreted to the alveolar space where it undergoes complex changes [2]. The composition of lung surfactant in humans is very constant, although it may change in diseas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2007
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.091157